LINKAGE OF EARLY-ONSET FAMILIAL BREAST CANCER TO CHROMOSOME 17Q21 PDF
PDF | Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Abstract, Full, Pdf. Apr , 3, 0, 0. May , 4, 0, 1. Jun , 2, 0, 0. Jul , 19, 0, 2. Aug , 21, 0, 1. Sep , 47, 0, 0. Oct , , 0, Nov PubMed journal article Linkage of early-onset familial breast cancer to chromosome 17q2 were found in PRIME PubMed. Download Prime PubMed App to.
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Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease.
Am J Hum Genet. See Am J Hum Genet. Genetic analysis of breast cancer in the cancer and steroid hormone study. Associated Data Supplementary Materials.
However, for late-onset cases, the relative probability breasy sporadic rather than inherited disease is higher than previously suggested. Segregation and linkage analysis of nine Utah breast cancer pedigrees. This article has been cited by other articles in PMC. If this correction is made, then later-onset families are much less informative; linkage heterogeneity based on age at onset 17q211 no longer significant; and for the sample of families as a whole, linkage is significant at a recombination fraction since demonstrated to be close to the correct local.
Strategies for multilocus linkage analysis in humans. Estimating the power of linkage analysis in hereditary breast cancer. Author information Copyright and License information Disclaimer. Abstract Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is restricted to early-onset disease.
– Document – Linkage of early-onset familial breast cancer to chromosome 17q21
There is probably more than one gene for inherited breast cancer, but heterogeneity may not lnikage due to age at disease onset. The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. Lod scores for linkage between familial breast and ovarian cancer and markers on chromosome 17q21 are more frequently positive among families with disease diagnosed at younger ages than they are among older-onset families, suggesting that linkage is early-onaet to early-onset disease.
Inheritance of proliferative breast disease in breast cancer kindreds. Closing in on a breast cancer gene on chromosome 17q. Support Center Support Center. This article has been corrected. Linkage of early-onset familial breast cancer to chromosome 17q