EPANUTIN INJECTION PDF

Phenytoin Injection prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side. Page 1. Page 4. Malta ADR Reporting website: adrportal 5. How to store Epanutin RMP The storage of Epanutin RMP will not be . Epanutin Injection is used for Seizure, Migraine, Cardiac arrhythmias and other conditions. Epanutin Injection may also be used for purposes not listed in this.

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Pro-Epanutin should not be used in women of childbearing potential injecton other antiepileptic drugs are ineffective or not tolerated and when possible, the woman is made aware of the risk of potential harm to the foetus and the importance of planning pregnancy.

There have been isolated reports of malignancies, including neuroblastoma, in children whose mothers received phenytoin during pregnancy.

These side-effects are possible, but do not knjection occur. Intra-arterial administration must be avoided in view of the high pH of the preparation. Determination of plasma phenytoin concentrations is especially helpful when possible drug interactions are suspected see section 4.

Pro-Epanutin Concentrate for Infusion / Solution for Injection

Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Fertility In animal studies, fosphenytoin had no effect on fertility in male rats but decreased fertility in female rats see section 5. Precautions Before using Epanutin Injectioninform your doctor about your current list of medications, over the counter products e. The adverse event profile of phenytoin is generally injecttion between children and adults.

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Caution is recommended in patients performing skilled tasks e.

Epanutin Injection – Uses, Side-effects, Reviews, and Precautions – TabletWise – UAE

To bookmark a medicine you must sign up and log in. If the patient requires more than a week of intramuscular Epanutin, alternative routes should be explored such as gastric intubation. Antineoplastic agents fluorouracil Azole antifungals ketoconazole, itraconazole, fluconazole, miconazole Capecitabine Fluvastatin Glibenclamide Sulfaphenazole. The clinical course of acute phenytoin hepatotoxicity ranges from injction recovery to fatal outcomes.

Early withdrawal is associated with a better prognosis. Total exchange transfusion has been used in the treatment of severe intoxication in children.

Fertility In animal studies, phenytoin had no direct effect on fertility. In a patient having continuous seizure activity, as compared to the more common rapidly recurring seizures, i. Generic Name and Formulations: Prior to complete conversion, immunoanalytical techniques may significantly overestimate epajutin phenytoin concentrations due to cross-reactivity with fosphenytoin.

The solution should be injected slowly, intravenously and at a uniform rate which should not exceed 1 ml 50 mg per minute.

Dermatological manifestations sometimes accompanied by fever have included scarlatiniform or morbilliform rashes. The other ingredients are propylene glycol, ethanol alcoholsodium hydroxide and water for injection.

Phenytoin Injection Dosage & Rx Info | Uses, Side Effects – MPR

The fraction of unbound phenytoin is increased in patients with renal or hepatic disease, or in those iniection hypoalbuminaemia.

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Any unused medicinal product or waste should be disposed of in accordance with local requirements. These have included thrombocytopenia, leucopenia, granulocytopenia, agranulocytosis, and pancytopenia with or without epanuutin marrow suppression and aplastic anaemia.

No developmental effects were observed in offspring of pregnant rabbits given fosphenytoin; malformations have been reported in offspring of pregnant rabbits given phenytoin. Tonic convulsions have also been reported. Epanutin RMP contains ethanol and sodium This medicinal product contains 8. There are many drugs that may increase or decrease serum phenytoin levels or that phenytoin may affect. Table 2 displays dosing information for status epilepticus maintenance dose in adults.

Each injection or infusion of intravenous Epanutin should nijection preceded and followed by an injection of sterile saline through the same needle or catheter to avoid local venous irritation due to alkalinity of the solution see section 4. Each 5 ml also contains Phenytoin does not interfere with uptake and suppression tests used in the diagnosis of epannutin. This is not normally continued for longer than one week.

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