Elastosis perforans serpiginosa (EPS) is a rare disorder classified as a primary perforating dermatosis. That group of diseases also includes. Four types of elastosis perforans serpiginosa (EPS) have been described in literature: 1) idiopathic EPS, 2) reactive perforating elastosis. Elastosis perforans serpiginosa (EPS) is a rare dermatologic condition where connective and elastic tissues are viewed as foreign objects and subsequently.

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Elastosis perforans serpiginosa – Wikipedia

There is no effective standard treatment of EPS, perforanss so far there have been only single reports of the use of different drugs for systemic and topical therapy [ 2 ]. This article has been cited by other articles in PMC. The first one, known as reactive one, is associated with connective tissue diseases, such as Ehlers-Danlos syndrome type IVcutis laxa, Marfan syndrome, acrogeria, Rothmund-Thomson syndrome, osteogenesis imperfecta and pseudoxanthoma elasticum [ 3 — 6 ].

You can help Wikipedia by expanding it. Published online Oct In addition, discontinuing penicillamine therapy does not guarantee preventing further development of EPS lesions in patients undergoing penicillamine elastossis 15 Moreover, even though transepidermal elimination can occur in any of the three other perforating diseases, the elastic tissue changes present in EPS are virtually pathognomonic.

Please review our privacy policy. There is no cure for EPS. At the 1-month follow-up visits, their disease was somewhat improved. Tazarotene is an effective therapy for elastosis perforans serpiginosa. Saxena M, Tope WD.


Elastosis perforans serpiginosa: a review of the literature and our own experience

The amount and thickness of the elastic fibers in the papillary dermis had increased markedly. Burkhart and Burkhart 5 reported tazarotene’s effectiveness in treating a patient with Darier disease who had responded poorly to other agents.

Chilblain Lupus erythematosus—lichen planus overlap syndrome Tumid Verrucous Rowell’s syndrome. An elastic stain demonstrated an serpgiinosa concentration of elastic fibers in the middermis extending to the epidermis.

Elastosis perforans serpiginosa

InLutz described the morphology of EPS and named it serpiginosa follicular keratosis. Also, the blockage of retinoic acid receptors may play a role in decreasing the proliferation in EPS. segpiginosa

It looked like entering the canals toward the outside of the skin Fig. Please review our privacy policy. The last subtype, idiopathic one, may be associated with genetic basis of the autosomal dominant type of inheritance. The disease prevalence has not been clearly specified so far but this is not a condition commonly found in routine clinical practice. Acquired disorders of elastic tissue: Open in a separate window.

Elastosis perforans serpiginosa associated with pseudo-pseudoxanthoma elasticum during treatment of Wilson’s disease with penicillamine. D-penicillamine induced EPS has a distinctive histopathologic feature – serrated appearance of elastic fibers due to perpendicular budding from their surface giving a “lumpy-bumpy” look.

In addition, they are mostly single, and the presence of numerous scattered plaques is atypical. Keloid Hypertrophic scar Cutis verticis gyrata. Elastosis perforans serpiginosa EPS is serpiginosq rare skin disorder in which abnormal elastic tissue fibre passes from the papillary dermis inner layer of skin to the epidermis outer layer of skin.


The skin at the entrance of the tunnel accumulates chronic inflammatory infiltrate composed often of giant cells [ 1112 ].

Imiquimod therapy for elastosis perforans serpiginosa. Localized idiopathic elastosis perforans serpiginosa effectively treated by the Coherent Ultrapulse C aesthetic laser.

Elastosis perforans serpiginosa | DermNet NZ

Lichen sclerosus Anetoderma Schweninger—Buzzi anetoderma Jadassohn—Pellizzari anetoderma Atrophoderma of Pasini and Pierini Acrodermatitis chronica atrophicans Semicircular lipoatrophy Follicular atrophoderma Linear atrophoderma of Moulin. Brown papules coalescing to form serpiginous plaques with central clearing, atrophy and raised hyperkeratotic rim over sides of the neck Click here to view.

A case of elastosis perforans serpiginosa associated with pseudoxanthoma elasticum. Localized scleroderma Localized morphea Morphea—lichen sclerosus et atrophicus overlap Generalized morphea Atrophoderma of Pasini and Pierini Pansclerotic morphea Morphea profunda Linear scleroderma. Disorders of connective tissue. In addition, the patient was suffering from hypothyroidism, tetralogy of Fallot and bilateral congenital dislocation of the hip joints.

Partially the parakeratotic keratin plug contains an addition of basophilic masses and crumbled nuclei of inflammatory cells.

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